Antiretroviral inhibitors that are used to manage HIV infection/AIDS predominantly target
three enzymes required for virus replication: reverse transcriptase, protease, and integrase …

The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the
cytoplasm and is responsible for mediating communication by regulating the transport of …

Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In
unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the …

Integrase (IN) strand transfer inhibitors (INSTIs) have been developed to inhibit the ability of
HIV-1 integrase to irreversibly link the reverse-transcribed viral DNA to the host genome …

The human immunodeficiency virus 1 (HIV-1) synthesizes its genomic DNA in cytoplasm as
soon as it enters the cell. The newly synthesized DNA remains associated with viral/cellular …

The primary roles of the human immunodeficiency virus type 1 (HIV-1) capsid (CA) protein
are to encapsidate and protect the viral RNA genome. It is becoming increasing apparent …

In this study, we examined the requirement for host dynein adapter proteins such as dynein
light chain 1 (DYNLL1), dynein light chain Tctex-type 1 (DYNLT1), and p150Glued in early …

Transportin 3 (TNPO3 or TRN-SR2) has been shown to be an important cellular factor for
early steps of lentiviral replication. However, separate studies have implicated distinct …

Although all HIV drugs developed to date are prone to the problem of drug resistance, there
is hope that second generation integrase inhibitors may prove to be relatively resilient to this …

Recent mutations selected in vitro with second-generation INSTIs suggest the existence of
low levels of cross-resistance between these drugs and first-generation compounds. In …