Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …

Simple Summary Glioblastoma is the most common malignant primary brain tumor in adults.
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …

The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse
intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to …

Point mutations within the histone H3. 3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …

Background Considering that pediatric high-grade gliomas (HGGs) are biologically distinct
from their adult counterparts, the objective of this study was to define the landscape of HGGs …

AbstractAs a cancer predisposition syndrome, individuals with neurofibromatosis type 1
(NF1) are at increased risk for the development of both benign and malignant tumors. One of …

Brain tumors represent the leading cause of disease-related mortality and morbidity in
children, with effective treatments urgently required. One factor limiting the effectiveness of …

Abstract Purpose of Review H3K27M is a frequent histone mutation within diffuse midline
gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO …

The 2021 World Health Organization Classification of Tumors of the Central Nervous System
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …

We analyzed the contributions of structural variants (SVs) to gliomagenesis across 179
pediatric high-grade gliomas (pHGGs). The most recurrent SVs targeted MYC isoforms and …