Background The existing estimate of the global burden of latent TB infection (LTBI) as “one-
third” of the world population is nearly 20 y old. Given the importance of controlling LTBI as …

Background Every year, an estimated one million children and young adolescents become
ill with tuberculosis, and around 226,000 of those children die. Xpert MTB/RIF Ultra (Xpert …

We currently have a binomial approach to managing tuberculosis. Those with active
disease, ideally confirmed microbiologically, are treated with a standard 6-month, multi-drug …

Background Every year, at least one million children become ill with tuberculosis and
around 200,000 children die. Xpert MTB/RIF and Xpert Ultra are World Health Organization …

Background Many children who develop tuberculosis are thought to be missed by diagnostic
and reporting systems. We aimed to estimate paediatric tuberculosis incidence and …

The successful care of children and adolescents with TB requires a recognition of the risk
factors and clinical and radiographic signs of TB, especially when microbiologic testing is …

Rapid, sensitive, accurate and portable diagnostics are a mainstay of modern medicine.
Tuberculosis is a disease that has been with us since time immemorial and, despite the fact …

Abstract In 2015, the World Health Organization (WHO) declared tuberculosis (TB) to be
responsible for more deaths than any other single infectious disease. The burden of TB …

The management of childhood tuberculosis (TB) is hampered by the low sensitivity and
limited accessibility of microbiological testing. Optimizing clinical approaches is therefore …

Tuberculosis (TB) remains a significant, yet under-recognized cause of death in the pediatric
population, with a WHO estimate of 1 million new cases of childhood TB in 2016 resulting in …