Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …

Cultivated mammalian cells have become the dominant system for the production of
recombinant proteins for clinical applications because of their capacity for proper protein …

Eukaryotic chromosomes are organized inside the nucleus in such a way that only a subset
of the genome is expressed in any given cell type, but the details of this organization are …

Eukaryotic chromosomes are packaged in nuclei by many orders of folding. Little is known
about how higher-order chromatin packaging might affect gene expression. SATB1 is a cell …

Nuclear matrix attachment regions (MARs) are regulatory DNA sequences that are important
for higher-order chromatin organization, long-range enhancer function, and extension of …

Mammalian genomes are compartmentalized into dense inactive chromatin that is
hypermethylated and active open chromatin that is hypomethylated. It is generally accepted …

Pairing of homologous chromosomes is an essential feature of meiosis, acting to promote
high levels of recombination and to ensure segregation of homologs. However, homologous …

For many, if not most genes, the initiation of transcription is the principle point at which their
expression is regulated. Transcription factors, some of which bind to specific DNA …

The combinatorial interaction among transcription factors is believed to determine
hematopoietic cell fate. Stem cell leukemia (SCL, also known as TAL1 [T-cell acute …

Histone acetylation is an important regulatory mechanism that controls transcription and
diverse nuclear processes. While great progress has been made in understanding how …