One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Background & Aims When the glial fibrillary acidic protein (GFAP) promoter is used to
express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and …

Highlights•Enteric glial cells (EGCs) are required for maintenance of gut tissue
homeostasis.•GFAP+ EGCs regulate the health of the intestinal epithelial barrier.•EGCs …

The disruption of the intestinal epithelial barrier function occurs commonly in various
pathologies, but the exact mechanisms responsible are unclear. The H19 long noncoding …

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract
responsible for intestinal lesions. The multifactorial etiology attributed to CD includes a …

Enteric glia are the partners of neurons in the enteric nervous system throughout the
gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining …

As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …

The intestinal epithelial barrier is the largest exchange surface between the body and the
external environment. Its functions are regulated by luminal, and also internal, components …