An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …

Anti-inflammation activity of flavones and their structure–activity relationship

X Wang, Y Cao, S Chen, J Lin, J Bian… - Journal of Agricultural …, 2021 - ACS Publications
Flavones are an important class of bioactive constituents in foods, and their structural
diversity enables them to interact with different targets. In particular, flavones are known for …

Understanding lignin aggregation processes. A case study: budesonide entrapment and stimuli controlled release from lignin nanoparticles

MH Sipponen, H Lange, M Ago… - … sustainable chemistry & …, 2018 - ACS Publications
The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated
by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation …

Inflammatory bowel disease: an overview of immune mechanisms and biological treatments

BRR de Mattos, MPG Garcia… - Mediators of …, 2015 - Wiley Online Library
Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the
intestinal tract associated with an imbalance of the intestinal microbiota. Crohn's disease …

Gut organoid as a new platform to study alginate and chitosan mediated PLGA nanoparticles for drug delivery

Z Davoudi, N Peroutka-Bigus, B Bellaire, A Jergens… - Marine drugs, 2021 - mdpi.com
Intestinal organoids can be used as an ex vivo epithelial model to study different drug
delivery effects on epithelial cells' luminal surface. In this study, the impact of surface charge …

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

S Gordon, M Daneshian, J Bouwstra, F Caloni… - …, 2015 - researchonline.ljmu.ac.uk
Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

Intestinal in vitro cell culture models and their potential to study the effect of food components on intestinal inflammation

MC Ponce de León-Rodríguez, JP Guyot… - Critical reviews in …, 2019 - Taylor & Francis
Cell cultures are widely used in pharmaceutical, medical, food/nutrition and biological
sciences. In food and nutrition science, intestinal cell culture models of human origin are …

Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases

H Ali, B Weigmann, MF Neurath, EM Collnot… - Journal of Controlled …, 2014 - Elsevier
The purpose of this study was to investigate the therapeutic potential of budesonide loaded
nanocarriers for the treatment of inflammatory bowel disease (IBD). First, budesonide was …

Concern-driven integrated approaches to nanomaterial testing and assessment–report of the NanoSafety Cluster Working Group 10

AG Oomen, PMJ Bos, TF Fernandes… - …, 2014 - Taylor & Francis
Bringing together topic-related European Union (EU)-funded projects, the so-called
“NanoSafety Cluster” aims at identifying key areas for further research on risk assessment …