Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

The Myc oncogene regulates the expression of several components of the protein synthetic
machinery, including ribosomal proteins, initiation factors of translation, RNA polymerase III …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

The discussion on cell proliferation cannot be continued without taking a look at the cell
cycle regulatory machinery. Cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors …

Cyclin-dependent kinases 4 and 6 (Cdk4/6) are important components of cell cycle
activation and control in early G1 phase. Both enzymes and their regulators, eg, cyclins, play …

Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11p110)
throughout the cell cycle and a 58-kDa protein (CDK11p58) that is specifically translated …

Both mitosis and autophagy are highly regulated dynamic cellular processes and involve
various phosphorylation events catalysed by kinases, which play vital roles in almost all …

Among cellular kinases, several cell cycle protein kinases play critical roles in mitotic entry
and chromosome segregation. Inhibition of these proteins frequently results in dramatic …