OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …

Drug-associated dysfunction of mitochondria is believed to play a role in the etiology of the
various adverse symptoms that occur in human immunodeficiency virus (HIV)-infected …

Nucleoside reverse transcriptase inhibitors (NRTIs) remain the cornerstone of highly active
antiretroviral therapy (HAART) combination regimens. However, it has been known for some …

Clinical studies with tenofovir disoproxil fumarate, an oral prodrug of the nucleotide analog
tenofovir, recently approved for the treatment of HIV, have demonstrated antiviral activity and …

Nucleoside analogs are associated with various mitochondrial toxicities, and it is becoming
increasingly difficult to accommodate these differences solely in the context of DNA …

The transport of metabolites, nucleotides and cofactors across the mitochondrial inner
membrane is performed by members of mitochondrial carrier family (MCF). These proteins …

Background Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma
disorders present low survival and high mortality rates and are challenging to diagnose and …

Objective: To investigate progressive, severe neuromuscular weakness associated with
lactic acidosis in some HIV-infected patients after exposure to nucleoside reverse …

We have investigated whether nucleoside drugs that induce or protect neurones against
apoptosis might directly activate or inhibit mitochondrial permeability transition (mPT) since …

Long-term side effects of antiretroviral therapy are attributed to the mitochondrial (mt) toxicity
of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and their ability to deplete …