Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
The effects of acute exercise on mood, cognition, neurophysiology, and neurochemical pathways: a review
A significant body of work has investigated the effects of acute exercise, defined as a single
bout of physical activity, on mood and cognitive functions in humans. Several excellent …
bout of physical activity, on mood and cognitive functions in humans. Several excellent …
Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
Objective: The long-term efficacy and safety of responsive direct neurostimulation was
assessed in adults with medically refractory partial onset seizures. Methods: All participants …
assessed in adults with medically refractory partial onset seizures. Methods: All participants …
Hippocampal neurogenesis regulates forgetting during adulthood and infancy
Throughout life, new neurons are continuously added to the dentate gyrus. As this
continuous addition remodels hippocampal circuits, computational models predict that …
continuous addition remodels hippocampal circuits, computational models predict that …
Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal …
CN Heck, D King‐Stephens, AD Massey, DR Nair… - …, 2014 - Wiley Online Library
Objective To demonstrate the safety and effectiveness of responsive stimulation at the
seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with …
seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with …
Adult hippocampal neurogenesis and its role in Alzheimer's disease
Y Mu, FH Gage - Molecular neurodegeneration, 2011 - Springer
The hippocampus, a brain area critical for learning and memory, is especially vulnerable to
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …
Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …
[HTML][HTML] Probing and regulating dysfunctional circuits using deep brain stimulation
AM Lozano, N Lipsman - Neuron, 2013 - cell.com
Despite the best available medical treatments, many patients continue to be disabled by
neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging …
neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging …
A phase II study of fornix deep brain stimulation in mild Alzheimer's disease
AM Lozano, L Fosdick, MM Chakravarty… - Journal of …, 2016 - content.iospress.com
Background: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional
brain circuits. The safety and efficacy of DBS in dementia is unknown. Objective: To assess …
brain circuits. The safety and efficacy of DBS in dementia is unknown. Objective: To assess …
Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus
Deep brain stimulation (DBS) is a promising neuromodulation therapy, but the
neurophysiological mechanisms of DBS remain unclear. In awake mice, we performed high …
neurophysiological mechanisms of DBS remain unclear. In awake mice, we performed high …