As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Natural products that contain functional groups with heteroatom-heteroatom linkages (X–X,
where X= N, O, S, and P) are a small yet intriguing group of metabolites. The reactivity and …

The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Cytochrome P450 enzymes catalyze a broad diversity of reactions, including well-
established transformations such as carbon and nitrogen hydroxylation, heteroatom …

The tire rubber antioxidant N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD)
and its quinone product (6PPDQ) are prevalent emerging contaminants, yet their …

Drugs containing thiazole and aminothiazole groups are known to generate reactive
metabolites (RMs) catalyzed by cytochrome P450s (CYPs). These RMs can covalently …

Drugs that inhibit cytochrome P450 (P450) enzymes through mechanism-based inactivation
(MBI) can significantly affect metabolic interactions, often leading to adverse effects. Despite …

5-Lipoxygenase activating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway
activity and reduce the production of proinflammatory and vasoactive leukotrienes. As such …

Heterocyclic aromatic amines (HAAs) are primarily produced during the heating of meat or
fish. HAAs are mutagenic and carcinogenic, and their toxicity in model systems depend on …