Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

Research into cardiac autonomic control has received great interest in the past 20 years,
and we are now at a critical juncture with regard to the clinical translation of the experimental …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

A constant supply of oxygen is indispensable for cardiac viability and function. However, the
role of oxygen and oxygen-associated processes in the heart is complex, and they and can …

In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …