Fluorinated amino acids: compatibility with native protein structures and effects on protein–protein interactions
M Salwiczek, EK Nyakatura, UIM Gerling… - Chemical Society …, 2012 - pubs.rsc.org
Fluorinated analogues of the canonical α-L-amino acids have gained widespread attention
as building blocks that may endow peptides and proteins with advantageous biophysical …
as building blocks that may endow peptides and proteins with advantageous biophysical …
19F NMR: a valuable tool for studying biological events
With the spectacular advancement of NMR techniques and the flourishing of fluorine
chemistry allowing the synthesis of various fluorinated molecules, 19F NMR represents a …
chemistry allowing the synthesis of various fluorinated molecules, 19F NMR represents a …
A supramolecular approach to combining enzymatic and transition metal catalysis
ZJ Wang, KN Clary, RG Bergman, KN Raymond… - Nature …, 2013 - nature.com
The ability of supramolecular host–guest complexes to catalyse organic reactions
collaboratively with an enzyme is an important goal in the research and discovery of …
collaboratively with an enzyme is an important goal in the research and discovery of …
Ligand-based fluorine NMR screening: principles and applications in drug discovery projects
C Dalvit, A Vulpetti - Journal of medicinal chemistry, 2018 - ACS Publications
Ligand-based fluorine NMR screening has gained popularity in drug discovery projects
during the past decade and has become a powerful methodology to produce high quality …
during the past decade and has become a powerful methodology to produce high quality …
Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives
B Linclau, A Ardá, NC Reichardt, M Sollogoub… - Chemical Society …, 2020 - pubs.rsc.org
This review provides an extensive summary of the effects of carbohydrate fluorination with
regard to changes in physical, chemical and biological properties with respect to regular …
regard to changes in physical, chemical and biological properties with respect to regular …
Current applications of 19F NMR to studies of protein structure and dynamics
JL Kitevski-LeBlanc, RS Prosser - Progress in nuclear magnetic resonance …, 2012 - Elsevier
While traditional 1H, 13C, and 15N (HCN) solution state NMR protocols provide a wealth of
data on protein structure and dynamics, 19F NMR provides a unique perspective of …
data on protein structure and dynamics, 19F NMR provides a unique perspective of …
Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights
R Filler, R Saha - Future medicinal chemistry, 2009 - Taylor & Francis
This perspective explores the origins of both fluorine and medicinal chemistry a century ago
and traces the early history of the intersection of these areas and the subsequent roles that …
and traces the early history of the intersection of these areas and the subsequent roles that …
19F NMR as a tool in chemical biology
We previously reviewed the use of 19 F NMR in the broad field of chemical biology [Cobb,
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …
Beyond the Balz–Schiemann reaction: the utility of tetrafluoroborates and boron trifluoride as nucleophilic fluoride sources
AJ Cresswell, SG Davies, PM Roberts… - Chemical …, 2015 - ACS Publications
Fluorine is the 13th most abundant element in the Earth's crust, and yet, despite its relatively
high profusion, organofluorine compounds are scarce in nature, with only around a dozen …
high profusion, organofluorine compounds are scarce in nature, with only around a dozen …
Using 19F NMR to Probe Biological Interactions of Proteins and Peptides
ENG Marsh, Y Suzuki - ACS chemical biology, 2014 - ACS Publications
Fluorine is a valuable probe for investigating the interactions of biological molecules
because of its favorable NMR characteristics, its small size, and its near total absence from …
because of its favorable NMR characteristics, its small size, and its near total absence from …