Fluorinated analogues of the canonical α-L-amino acids have gained widespread attention
as building blocks that may endow peptides and proteins with advantageous biophysical …

With the spectacular advancement of NMR techniques and the flourishing of fluorine
chemistry allowing the synthesis of various fluorinated molecules, 19F NMR represents a …

The ability of supramolecular host–guest complexes to catalyse organic reactions
collaboratively with an enzyme is an important goal in the research and discovery of …

Ligand-based fluorine NMR screening has gained popularity in drug discovery projects
during the past decade and has become a powerful methodology to produce high quality …

This review provides an extensive summary of the effects of carbohydrate fluorination with
regard to changes in physical, chemical and biological properties with respect to regular …

While traditional 1H, 13C, and 15N (HCN) solution state NMR protocols provide a wealth of
data on protein structure and dynamics, 19F NMR provides a unique perspective of …

This perspective explores the origins of both fluorine and medicinal chemistry a century ago
and traces the early history of the intersection of these areas and the subsequent roles that …

We previously reviewed the use of 19 F NMR in the broad field of chemical biology [Cobb,
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …

Fluorine is the 13th most abundant element in the Earth's crust, and yet, despite its relatively
high profusion, organofluorine compounds are scarce in nature, with only around a dozen …

Fluorine is a valuable probe for investigating the interactions of biological molecules
because of its favorable NMR characteristics, its small size, and its near total absence from …