Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Huntington disease (HD) is a fatal progressive neurodegenerative disorder caused by an
inherited mutation in the huntingtin (HTT) gene, which encodes mutant HTT protein. Though …

Huntington disease (HD) is caused by an expansion mutation of the N-terminal
polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable …

Neurodegenerative diseases (NDDs) are disorders characterized by progressive
deterioration of brain structure and function. Selective neuronal populations are affected …

Huntington disease (HD) is an inherited neurodegenerative disorder caused by an
expansion of the CAG repeat region in the first exon of the huntingtin gene …

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative
disorder caused by expanded CAG trinucleotide repeats (> 36) in exon 1 of HTT gene that …

The CAG expansion of huntingtin (mHTT) associated with Huntington disease (HD) is a
ubiquitously expressed gene, yet it prominently damages the striatum and cortex, followed …

Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …

Huntington's disease (HD) is a lethal neurodegenerative disorder without efficient
therapeutic options. The inefficient translation from preclinical and clinical research into …

Huntington disease (HD) is a fatal neurodegenerative disorder caused by an autosomal
dominant CAG repeat expansion in the huntingtin (HTT) gene. The translated expanded …