[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …
pH sensitive hydrogels in drug delivery: Brief history, properties, swelling, and release mechanism, material selection and applications
Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed
rather than the development of novel drugs which involve much expense and time. The …
rather than the development of novel drugs which involve much expense and time. The …
Nanoparticles: oral delivery for protein and peptide drugs
S Cao, S Xu, H Wang, Y Ling, J Dong, R Xia, X Sun - Aaps Pharmscitech, 2019 - Springer
Protein and peptide drugs have many advantages, such as high bioactivity and specificity,
strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of …
strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of …
Approaches for enhancing oral bioavailability of peptides and proteins
J Renukuntla, AD Vadlapudi, A Patel… - International journal of …, 2013 - Elsevier
Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …
Emerging micro-and nanotechnology based synthetic approaches for insulin delivery
Insulin is essential for type 1 and advanced type 2 diabetics to maintain blood glucose levels
and prolong lives. The traditional administration requires frequent subcutaneous insulin …
and prolong lives. The traditional administration requires frequent subcutaneous insulin …
Oral insulin delivery platforms: strategies to address the biological barriers
Diabetes mellitus is a lifelong metabolic disease that requires frequent subcutaneous
injections of insulin. However, this method of administration can be associated with patient …
injections of insulin. However, this method of administration can be associated with patient …
Chitosan-based nanoparticles: An overview of biomedical applications and its preparation
S Naskar, S Sharma, K Kuotsu - Journal of Drug Delivery Science and …, 2019 - Elsevier
Chitosan (CS) is one of the most successfully developed biodegradable polymers. Among
the numerous polymers developed to formulate polymeric nanoparticles, CS has fascinated …
the numerous polymers developed to formulate polymeric nanoparticles, CS has fascinated …
Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials
TAS Aguirre, D Teijeiro-Osorio, M Rosa… - Advanced drug delivery …, 2016 - Elsevier
The development of oral dosage forms that allows absorption of therapeutic peptides to the
systemic circulation is one of the greatest challenges for the pharmaceutical industry …
systemic circulation is one of the greatest challenges for the pharmaceutical industry …
Emerging theranostic nanomaterials in diabetes and its complications
Y Liu, S Zeng, W Ji, H Yao, L Lin, H Cui… - Advanced …, 2022 - Wiley Online Library
Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by
hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin …
hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin …
Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules
Chitosan (CS), a cationic polysaccharide, is widely regarded as a safe and efficient intestinal
absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive …
absorption enhancer of therapeutic macromolecules, owing to its inherent mucoadhesive …