Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

This review describes the most commonly used rodent models and outcome measures in
preclinical stroke research and discusses their strengths and limitations. Most models …

Importance Randomized clinical trials suggest the benefit of intravenous tissue-type
plasminogen activator (tPA) in acute ischemic stroke is time dependent. However, modest …

Background MRI-based selection of patients for acute stroke interventions requires rapid
accurate estimation of the infarct core on diffusion-weighted MRI. Typically used manual …

The concept of neuroprotective therapy for acute ischemic stroke to salvage tissue at risk
and improve functional outcome is based on sound scientific principles and extensive …

Over the past forty years, animal models of focal cerebral ischaemia have allowed us to
identify the critical cerebral blood flow thresholds responsible for irreversible cell death …

Stroke continues to be a significant cause of death and disability worldwide. Although major
advances have been made in the past decades in prevention, treatment, and rehabilitation …

Rodent models of focal cerebral ischemia are essential tools in experimental stroke
research. They have added tremendously to our understanding of injury mechanisms in …

Stroke is the second most common cause of death and is a major cause of permanent
disability. Given the current demographic trend of an ageing population and associated …

Stroke is a leading cause of disability and death in many countries. Understanding the
pathophysiology of ischemic injury and developing therapies is an important endeavor that …