Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …

Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of
cancerous cells. Targeted induction of mitochondrial dysfunction in cancer cells by …

Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations,
activating oncogenes, and raising oxidative stress, which all influence cell proliferation …

Melatonin helps to maintain circadian rhythm, exerts anticancer activity, and plays key roles
in regulation of glucose homeostasis and energy metabolism. Glycosylation, a form of …

Melatonin is a multifunctional hormone that has long been known for its antitumoral effects.
An advantage of the application of melatonin in cancer therapy is its ability to differentially …

Several drug targets have been amenable to drug discovery pursuit not until the
characterization of the mitochondrial permeability transition pore (MPTP), a pore with an …

Abstract Triple Negative Breast Cancer (TNBC) is an aggressive tumour with patients
survival rarely exceeding five years. TNBC tumours are larger in size, more chemoresistant …

Mitochondria have various cellular functions, including ATP synthesis, calcium homeostasis,
cell senescence, and death. Mitochondrial dysfunction has been identified in a variety of …

The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase
that plays important roles in many cellular functions including cell motility and survival. The …