Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

The anaphase promoting complex/cyclosome (APC/C), is an evolutionarily conserved
protein complex essential for cellular division due to its role in regulating the mitotic …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

Genetic variations along with epigenetic modifications of DNA are involved in colorectal
cancer (CRC) development and progression. CRC is the fourth leading cause of cancer …

Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

Angiogenesis and apoptosis are critical for the growth of colorectal cancer (CRC). The study
aimed to investigate the effects of TGM2 in CRC. Forty-two patients were recruited and their …

Objective Wnt/β‑catenin signaling pathway plays important role in colorectal cancer (CRC)
and acts as a potential therapeutic target. Pimozide is a FDA-approved clinical drug used to …

Natural products play important roles in the pathogenesis of many human malignancies,
including colorectal cancer, and can act as a gene regulator in many cancers. They regulate …

Background Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM
alternative splicing and promoting the expression of PKM2. Majority of the alternative …

The high abundance of drug efflux pumps in cancer stem cells (CSCs) contributes to
chemotherapy resistance. The transcriptional regulator SMAR1 suppresses CSC expansion …