Opportunities and challenges in long-read sequencing data analysis
Long-read technologies are overcoming early limitations in accuracy and throughput,
broadening their application domains in genomics. Dedicated analysis tools that take into …
broadening their application domains in genomics. Dedicated analysis tools that take into …
Orchestrating single-cell analysis with Bioconductor
Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …
genome-wide features in individual cells. However, single-cell data present unique …
[HTML][HTML] Loss of epigenetic information as a cause of mammalian aging
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …
epigenetic information. In yeast, epigenetic information is lost over time due to the …
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
Abstract N 6-methyladenosine (m6A), the most abundant internal messenger RNA
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
Haplotype-resolved diverse human genomes and integrated analysis of structural variation
INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …
understanding human health and disease. Recent technological advances have made it …
[HTML][HTML] MYB orchestrates T cell exhaustion and response to checkpoint inhibition
C Tsui, L Kretschmer, S Rapelius, SS Gabriel… - Nature, 2022 - nature.com
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
p21 produces a bioactive secretome that places stressed cells under immunosurveillance
I Sturmlechner, C Zhang, CC Sine, EJ van Deursen… - Science, 2021 - science.org
INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet
Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve
cereal production and quality, and ensure food security. Here we present the genetic …
cereal production and quality, and ensure food security. Here we present the genetic …