Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes
Cardiac arrhythmias are a prevalent cause of morbidity and mortality. In many cases,
inheritable mutations in the genes encoding cardiac ion channels are the underlying cause …
inheritable mutations in the genes encoding cardiac ion channels are the underlying cause …
Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation
E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the
cardiac voltage-gated sodium channel NaV1. 5. E1784K shifts the midpoint of the channel …
cardiac voltage-gated sodium channel NaV1. 5. E1784K shifts the midpoint of the channel …