Primary open-angle glaucoma

RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells

WK Ju, GA Perkins, KY Kim, T Bastola, WY Choi… - Progress in Retinal and …, 2023 - Elsevier
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

P Gharahkhani, E Jorgenson, P Hysi… - Nature …, 2021 - nature.com
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-
wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide …

Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

JE Craig, X Han, A Qassim, M Hassall… - Nature …, 2020 - nature.com
Glaucoma, a disease characterized by progressive optic nerve degeneration, can be
prevented through timely diagnosis and treatment. We characterize optic nerve photographs …

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma

AP Khawaja, JN Cooke Bailey, NJ Wareham… - Nature …, 2018 - nature.com
Glaucoma is the leading cause of irreversible blindness globally. Despite its gravity, the
disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is …

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

JNC Bailey, SJ Loomis, JH Kang, RR Allingham… - Nature …, 2016 - nature.com
Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To
identify new susceptibility loci, we performed meta-analysis on genome-wide association …

Genetics of glaucoma

JL Wiggs, LR Pasquale - Human molecular genetics, 2017 - academic.oup.com
Genetic and genomic studies, including genome-wide association studies (GWAS) have
accelerated the discovery of genes contributing to glaucoma, the leading cause of …

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

H Choquet, S Paylakhi, SC Kneeland, KK Thai… - Nature …, 2018 - nature.com
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet
much of the genetic risk remains unaccounted for, especially in African-Americans who have …

Retinal energy metabolism in health and glaucoma

RJ Casson, G Chidlow, JG Crowston… - Progress in Retinal and …, 2021 - Elsevier
Energy metabolism refers to the processes by which life transfers energy to do cellular work.
The retina's relatively large energy demands make it vulnerable to energy insufficiency. In …

Genetic risk scores

RP Igo Jr, TG Kinzy… - Current protocols in …, 2019 - Wiley Online Library
Genome‐wide variation data with millions of genetic markers have become commonplace.
However, the potential for interpretation and application of these data for clinical assessment …