α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,
animals, and humans. It has various properties, among them great antioxidant potential and …

The novel COVID-19 pandemic is affecting the world's population differently: mostly in the
presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal …

COVID-19, a respiratory disease caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), continues to spread across the globe. Predisposing factors such as age …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …

Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid.
Beneficial renal effects of some medications, such as chelation therapy depend at least …

Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative
stress that contributes to the pathogenesis of this debilitating disease. This has prompted …

Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to
excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Brain aging is associated with a progressive imbalance between antioxidant defenses and
intracellular concentrations of reactive oxygen species (ROS) as exemplified by increases in …