Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Exercise stimulates the release of proteins with autocrine, paracrine, or endocrine functions
produced in skeletal muscle, termed myokines. Based on the current state of knowledge, the …

Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …

The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …

Injuries to the musculoskeletal system are common, debilitating and expensive. In many
cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve …

Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue
healing leading to loss of its architecture and function. Fibrotic diseases are often associated …

In response to skeletal muscle injury, distinct cellular pathways are activated to repair the
damaged tissue. Activation and restriction of these pathways must be temporally …

Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth
factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly …

Aging in rodents and humans is characterized by loss of muscle mass (sarcopenia).
Testosterone supplementation increases muscle mass in healthy older men. Here, using a …