Macromolecular crowding, phase separation, and homeostasis in the orchestration of bacterial cellular functions
Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …
complexes in all cells, including bacteria. Crowding, together with physicochemical …
Influence of nonspecific interactions on protein associations: implications for biochemistry in vivo
The cellular interior is composed of a variety of microenvironments defined by distinct local
compositions and composition-dependent intermolecular interactions. We review the …
compositions and composition-dependent intermolecular interactions. We review the …
Membrane surfaces regulate assembly of ribonucleoprotein condensates
Biomolecular condensates organize biochemistry, yet little is known about how cells control
the position and scale of these structures. In cells, condensates often appear as relatively …
the position and scale of these structures. In cells, condensates often appear as relatively …
VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling
XK Gao, ZK Sheng, YH Lu, YT Sun, XS Rao, LJ Shi… - Cell discovery, 2023 - nature.com
The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been
recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However …
recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However …
SARS‐CoV‐2 biology and variants: anticipation of viral evolution and what needs to be done
The global propagation of SARS‐CoV‐2 and the detection of a large number of variants,
some of which have replaced the original clade to become dominant, underscores the fact …
some of which have replaced the original clade to become dominant, underscores the fact …
The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains
Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …
Melatonin: regulation of biomolecular condensates in neurodegenerative disorders
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …
chemically distinct subcellular compartments organizing macromolecules such as proteins …
Lipid Peroxidation Drives Liquid–Liquid Phase Separation and Disrupts Raft Protein Partitioning in Biological Membranes
M Balakrishnan, AK Kenworthy - Journal of the American …, 2024 - ACS Publications
The peroxidation of membrane lipids by free radicals contributes to aging, numerous
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …
Protein phase separation in plant membrane biology: more than just a compartmentalization strategy
JM Dragwidge, D Van Damme - The Plant Cell, 2023 - academic.oup.com
The formation of biomolecular condensates through phase separation is an important
strategy to compartmentalize cellular functions. While it is now well established that …
strategy to compartmentalize cellular functions. While it is now well established that …
Self-assembly of CIP4 drives actin-mediated asymmetric pit-closing in clathrin-mediated endocytosis
Y Yu, SH Yoshimura - Nature Communications, 2023 - nature.com
Clathrin-mediated endocytosis is pivotal to signal transduction pathways between the
extracellular environment and the intracellular space. Evidence from live-cell imaging and …
extracellular environment and the intracellular space. Evidence from live-cell imaging and …