Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

The fields of regenerative medicine and stem cell-based tissue engineering have the
potential of treating numerous tissue and organ defects. The use of adult stem cells is of …

The principles of formation, renewal, and eruption of teeth are discussed. Numerous genetic
aberrations may affect the formation and eruption of teeth. Cleidocranial dysplasia (CCD) …

The evolution of oral teeth is considered a major contributor to the overall success of jawed
vertebrates. This is especially apparent in cartilaginous fishes including sharks and rays …

Background Tooth is vital not only for a good smile, but also good health. Yet, we lose tooth
regularly due to accidents or diseases. An ideal solution to this problem is to regenerate …

The Wnt pathway is crucial for tooth development as shown by dental defects caused by
impaired Wnt signaling in mouse and human. We investigated Wnt signaling in continuously …

The tooth is an intricate composition of precisely patterned, mineralized matrices and soft
tissues. Mineralized tissues include enamel (produced by the epithelial cells called …

This review considers the diversity observed during both the development and evolution of
tooth replacement throughout the vertebrates in a phylogenetic framework from basal extant …

The face distinguishes one person from another. Postnatal orofacial tissues harbor rare cells
that exhibit stem cell properties. Despite unmet clinical needs for reconstruction of tissues …