The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

This review gives an account of how the cell repairs DNA damage and presents evidence
that DNA damage contributes to aging and cancer, with the outcome dependent on the type …

Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose
stress to cells and organisms by hindering DNA replication and transcription. In addition …

The ability to express or deplete proteins in living cells is crucial for the study of biological
processes. Viral vectors are often useful to deliver DNA constructs to cells that are difficult to …

Expressed genes are scanned by translocating RNA polymerases, which sensitively detect
DNA damage and initiate transcription-coupled repair (TCR), a subpathway of nucleotide …

Unstructured proteins, RNA or DNA components provide functionally important flexibility that
is key to many macromolecular assemblies throughout cell biology. As objective …

Trinucleotide expansion underlies several human diseases. Expansion occurs during
multiple stages of human development in different cell types, and is sensitive to the gender …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-
pathway of nucleotide excision repair that preferentially removes DNA lesions from the …