To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense
reactions, many of which are shared with higher organisms. These reactions include the use …

Sleep is controlled by two processes: a homeostatic drive that increases during waking and
dissipates during sleep, and a circadian pacemaker that controls its timing. Although these …

Social insects are able to mount both group‐level and individual defences against
pathogens. Here we focus on individual defences, by presenting a genome‐wide analysis of …

Background Recent genomic analyses of arthropod defense mechanisms suggest
conservation of key elements underlying responses to pathogens, parasites and stresses. At …

The response of drosophila to bacterial and fungal infections involves two signaling
pathways, Toll and Imd, which both activate members of the transcription factor NF-κB family …

To characterize the features of JAK/STAT signaling in Drosophila immune response, we
have identified totA as a gene that is regulated by the JAK/STAT pathway in response to …

Innate immune responses are mediated by the activation of various signaling processes.
Here, we describe our current knowledge on Janus kinase (JAK)/signal transducers and …

Heat shock proteins (Hsp) are involved in protein folding, transport and stress resistance.
Studies reporting an increased mRNA level of hsp genes in aged Drosophila suggest that …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling
pathway controls multiple biological processes in metazoan development and tissue …

During the past year, dramatic progress has been achieved in our understanding of
Drosophila immune reactions. The completion of the Drosophila genome sequencing …