An absolute, supraphysiologic elevation in GFR is observed early in the natural history in
10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover …

Diabetic kidney disease (DKD) represents a major component of the health burden
associated with type 1 and type 2 diabetes. Recent advances have produced an explosion …

OBJECTIVE To describe the prevalence and determinants of hyperfiltration (glomerular
filtration rate [GFR]≥ 120 mL/min/1.73 m2), GFR decline, and nephropathy onset or …

Aims/hypothesis Glomerular hyperfiltration is a well-established phenomenon occurring
early in some patients with type 1 diabetes. However, there is no consistent answer …

Background Established prediction models of Diabetic kidney disease (DKD) are limited to
the analysis of clinical research data or general population data and do not consider …

Aims Both reduced glomerular filtration and increased urinary albumin excretion
independently determine outcome in patients with chronic heart failure (HF). However …

Glomerular filtration rate is commonly elevated in early diabetes and patients with this
symptom are arbitrarily considered to have hyperfiltration. The prevalence of hyperfiltration …

OBJECTIVE To assess the performance of measurements of urinary albumin concentration
(UAC) and urinary albumin: creatinine ratio (UACR) in a diurnal random urine specimen …

Background Chronic kidney disease is an important concern in preventive medicine, but the
rate of decline in renal function in healthy population is not well defined. The purpose of this …

More than two decades ago, hyperfiltration (HF) in diabetes was postulated to be a
maladaptive response observed early in the course of diabetic kidney disease (DKD), which …