B lymphocytes have a central role in autoimmune diseases, which are often defined by
specific autoantibody patterns and feature a loss of B cell tolerance. A prototypic disease …

B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

Recent studies have identified critical roles for B cells in triggering autoimmune germinal
centers (GCs) in systemic lupus erythematosus (SLE) and other disorders. The mechanisms …

Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR)
and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B …

Dysregulated germinal center (GC) responses are implicated in the pathogenesis of human
autoimmune diseases, including systemic lupus erythematosus (SLE). Although both type 1 …

Expression of Toll-like receptors (TLRs) in B cells provides a cell-intrinsic mechanism for
innate signals regulating adaptive immune responses. In combination with other signaling …

B cells have been known for their ability to present antigens to T cells for almost 40 years.
However, the precise roles of B cell antigen presentation in various immune responses are …

Primary antibody deficiencies (PADs) are the most common inherited immunodeficiencies in
humans. The use of novel approaches, such as whole-exome sequencing and mouse …