[HTML][HTML] Preclinical and clinical sex differences in antipsychotic-induced metabolic disturbances: a narrative review of adiposity and glucose metabolism

LN Castellani, KA Costa-Dookhan… - Journal of psychiatry …, 2019 - ncbi.nlm.nih.gov
Antipsychotic (AP) medications are associated with an increased risk of developing
metabolic side effects including weight gain, type 2 diabetes (T2D), dyslipidemia, and …

Peripheral mechanisms of acute olanzapine induced metabolic dysfunction: a review of in vivo models and treatment approaches

H Shamshoum, KD Medak, DC Wright - Behavioural Brain Research, 2021 - Elsevier
Antipsychotic (AP) medications are associated with an increased risk for developing
metabolic side effects including weight gain, dyslipidemia, hypertension, type 2 diabetes …

Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice

GL McKie, KD Medak, CM Knuth… - The Journal of …, 2019 - Wiley Online Library
Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

Fasting or the short‐term consumption of a ketogenic diet protects against antipsychotic‐induced hyperglycaemia in mice

H Shamshoum, KD Medak, GL McKie… - The Journal of …, 2022 - Wiley Online Library
Antipsychotic (AP) medications, such as olanzapine (OLZ), are used in the treatment of
schizophrenia and a growing number of 'off‐label'conditions. A single dose of OLZ causes …

Acute administration of IL-6 improves indices of hepatic glucose and insulin homeostasis in lean and obese mice

WT Peppler, LK Townsend, GM Meers… - American Journal …, 2019 - journals.physiology.org
Obesity can lead to impairments in hepatic glucose and insulin homeostasis, and although
exercise is an effective treatment, the molecular targets remain incompletely understood. As …

GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia

KD Medak, H Shamshoum… - American Journal of …, 2020 - journals.physiology.org
Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of
schizophrenia and a number of off-label conditions. Although effective in reducing …

[HTML][HTML] Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice

F Ávila-Gámiz, AM Pérez-Cano, JM Pérez-Berlanga… - Physiology & …, 2023 - Elsevier
Combining physical and cognitive training has been suggested to promote further benefits
on brain and cognition, which could include synergistic improvement of hippocampal …

AMPK β1 activation suppresses antipsychotic‐induced hyperglycemia in mice

H Shamshoum, KD Medak, LK Townsend… - The FASEB …, 2019 - Wiley Online Library
Olanzapine (OLZ) is a second‐generation antipsychotic that is used to treat schizophrenia
but also causes acute hyperglycemia. This study aimed to determine if the ablation of AMPK …

Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein processing

DM Marko, MS Finch, AJT Yang… - Journal of Applied …, 2023 - journals.physiology.org
Exercise has been shown to be beneficial for individuals with Alzheimer's disease (AD). In
rodent models of AD, exercise decreases the amyloidogenic processing of the amyloid …

Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice

X Chen, Y Yu, P Zheng, T Jin, M He, M Zheng… - …, 2020 - Elsevier
Second generation antipsychotics, particularly olanzapine, induce severe obesity, which is
associated with their antagonistic effect on the histamine H1 receptor (H1R). We have …