Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

FMS‐like tyrosine kinase 3 (FLT3) is a type III receptor tyrosine kinase that plays an
important role in hematopoietic cell survival, proliferation and differentiation. The most …

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells,
and natural killer (NK) cells remains controversial and constitutes an important gap in the …

Simple Summary Cancer immunotherapy is currently focused mainly on the enhancement of
the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells …

FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …

As is the case for embryo-derived stem cells, application of reprogrammed human induced
pluripotent stem cells is limited by our understanding of lineage specification. Here we …

Normal haematopoietic cells use complex systems to control proliferation, differentiation and
cell death. The control of proliferation is, in part, accomplished through the ligand-induced …

The ligand for the receptor tyrosine kinase fms-like tyrosine kinase 3 (flt3), also referred to as
fetal liver kinase-2 (flk-2), has an important role in hematopoiesis. The flt3 ligand (flt3L) is a …

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

The production of hematopoietic cells is under the tight control of a group of hematopoietic
cytokines. Each cytokine has multiple actions mediated by receptors whose cytoplasmic …