Rats choose alcohol over social reward in an operant choice procedure

NJ Marchant, AJ McDonald, R Matsuzaki… - …, 2023 - nature.com
The interaction between social factors and alcohol addiction is complex, with potential for
both positive and negative contributions to drug use and abstinence. Positive social …

Gender differences in the psychosocial determinants underlying the onset and maintenance of alcohol use disorder

AM Maxwell, K Harrison, E Rawls… - Frontiers in …, 2022 - frontiersin.org
A large number of different mechanisms have been linked to Alcohol Use Disorder (AUD),
including psychosocial, neurocognitive, affective, and neurobiological factors. Gender has …

Sex-and age-specific effects on the development of addiction and compulsive-like drinking in rats

JC Foo, I Skorodumov, R Spanagel… - Biology of sex …, 2023 - Springer
Background Biological factors are known to influence disease trajectories and treatment
effectiveness in alcohol addiction and preclinical and clinical evidence suggests that sex is …

Sex-dependent divergence in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

C Díaz-Megido, M Thomsen - Psychopharmacology, 2023 - Springer
Rationale Alcohol use disorder remains a leading cause of preventable deaths, and current
treatments have limited efficacy. Glucagon-like peptide 1 (GLP-1) receptor agonists can …

[HTML][HTML] Impaired microglia-mediated synaptic pruning in the nucleus accumbens during adolescence results in persistent dysregulation of familiar, but not novel …

JM Kirkland, EL Edgar, I Patel, AM Kopec - bioRxiv, 2023 - ncbi.nlm.nih.gov
Evolutionarily conserved, peer-directed social behaviors are essential to participate in many
aspects of human society. These behaviors directly impact psychological, physiological, and …

Synaptic pruning during adolescence shapes adult social behavior in both males and females

JM Kirkland, EL Edgar, I Patel, P Feustel… - Developmental …, 2024 - Wiley Online Library
Evolutionarily conserved, peer‐directed social behaviors are essential to participate in many
aspects of human society. These behaviors directly impact psychological, physiological, and …

Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage …

SC Gironda, SW Centanni, JL Weiner - bioRxiv, 2024 - biorxiv.org
Early life stress (ELS) has lasting consequences on microglia and brain macrophage
function. During ELS, microglia and brain macrophages alter their engagement with …

From adolescence to adulthood: characterizing the enduring consequences of adolescent adversities in rats

AP Graf - 2024 - archiv.ub.uni-heidelberg.de
Here, we investigated the long-term effects of different types of adolescent adversities;
adolescent social isolation (ASI), social instability stress (SIS) and peer rejection (PR) in …

[引用][C] Sex differences in the effects of GLP-1 agonist exendin-4 on alcohol reinforcement and reinstatement in C57BL/6J mice

C Díaz-Megido, M Thomsen, M Thomsen, ES Allé