Histone methylation: at the crossroad between circadian rhythms in transcription and metabolism

M González-Suárez, L Aguilar-Arnal - Frontiers in Genetics, 2024 - frontiersin.org
Circadian rhythms, essential 24-hour cycles guiding biological functions, synchronize
organisms with daily environmental changes. These rhythms, which are evolutionarily …

Circadian interactomics: how research into protein-protein interactions beyond the core clock has influenced the model of circadian timekeeping

AE Mosier, JM Hurley - Journal of biological rhythms, 2021 - journals.sagepub.com
The circadian clock is the broadly conserved, protein-based, timekeeping mechanism that
synchronizes biology to the Earth's 24-h light-dark cycle. Studies of the mechanisms of …

Clockwork orange promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of clock interacting protein circadian

GBS Rivas, J Zhou, C Merlin, PE Hardin - Current Biology, 2021 - cell.com
The Drosophila circadian clock is driven by a transcriptional feedback loop in which CLOCK-
CYCLE (CLK-CYC) binds E-boxes to transcribe genes encoding the PERIOD-TIMELESS …

Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

A Scacchetti, T Schauer, A Reim, Z Apostolou… - Elife, 2020 - elifesciences.org
Histone acetylation and deposition of H2A. Z variant are integral aspects of active
transcription. In Drosophila, the single DOMINO chromatin regulator complex is thought to …

Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A

G Mahesh, GBS Rivas, C Caster, EB Ost… - Scientific Reports, 2020 - nature.com
Circadian clocks keep time via~ 24 h transcriptional feedback loops. In Drosophila, CLOCK-
CYCLE (CLK-CYC) activators and PERIOD-TIMELESS (PER-TIM) repressors are feedback …

CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters

CA Tabuloc, YD Cai, RS Kwok, EC Chan… - PLoS …, 2023 - journals.plos.org
Circadian clock and chromatin-remodeling complexes are tightly intertwined systems that
regulate rhythmic gene expression. The circadian clock promotes rhythmic expression …

Overexpression of α-synuclein in PDF neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila

D Xia, Y Chen, X Fu, HY Liu, MY Sun, F Wang, Y Zhang… - Sleep, 2024 - academic.oup.com
Parkinson's disease (PD) is a complex neurodegenerative disorder, characterized by the
aggregation of α-synuclein (α-syn). Current research increasingly indicates the prevalence …

The urban-adapted underground mosquito Culex pipiens form molestus maintains exogenously influenceable circadian rhythms

NR Epstein, K Saez, A Polat… - Journal of …, 2021 - journals.biologists.com
Genes known to affect circadian rhythms (ie 'clock genes') also influence the photoperiodic
induction of overwintering reproductive diapause in the northern house mosquito, Culex …

Targeted RNAi screen identifies transcriptional mechanisms that prevent premature degeneration of adult photoreceptors

SE Escobedo, SE McGovern… - … in epigenetics and …, 2023 - frontiersin.org
Aging is associated with a decline in visual function and increased prevalence of ocular
disease, correlating with changes in the transcriptome and epigenome of cells in the eye …

Characterizing the Role of Gene Regulatory Factors in Aging Drosophila Photoreceptors

S Escobedo - 2022 - search.proquest.com
Aging is associated with a decline in visual function and increased prevalence of ocular
disease, correlating with changes in the transcriptome and epigenome of cells in the eye …