Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest
cancers worldwide. Advanced HCC overall survival is meager and has not improved over …

The liver is an immunologically tolerant organ that is uniquely equipped to limit
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …

Biomarkers for early detection of breast cancer may complement population screening
approaches to enable earlier and more precise treatment. The blood proteome is an …

The liver is a lymphoid organ with unique immunological properties, particularly, its
predominant innate immune system. The balance between immune tolerance and immune …

The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view of NK
cells and provides another opportunity to study NK cells. Although evidence has suggested …

Checkpoint immunotherapy that targets inhibitory receptors of T cells, thereby reversing the
functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of …

Background Immune microenvironment is well recognized as a critical regulator across
cancer types, despite its complex roles in different disease conditions. Intrahepatic …

Background We aimed to construct and validate an energy metabolism-related gene
prognostic index (EMRGPI) to predict biochemical recurrence (BCR) in patients undergoing …

[Objective] Using multi-omics research methods to explore cytolytic activity-related genes
through the immunoregulatory factors HAVCR2 (TIM3) affecting the survival and prognosis …

ABSTRACT CCL22 is a macrophage-derived immunosuppressive chemokine that recruits
regulatory T cells through the CCL22: CCR4 axis. CCL22 was shown to play a key role in …