Glioblastoma (GBM) is a highly malignant type of primary brain tumor with a high mortality
rate. Although the current standard therapy consists of surgery followed by radiation and …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

The dynamic and reversible N 6-methyladenosine (m 6 A) RNA modification installed and
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …

Exhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their
ineffective reinvigoration limits the durable benefit in some cancer patients. Here, we …

Chronic stress triggers activation of the sympathetic nervous system and drives malignancy.
Using an immunodeficient murine system, we showed that chronic stress–induced …

Abstract PD-1 (CD279)–PD-L1 (CD274) inhibitory signaling is critical for cancer immune
evasion, and thus has become one of the major targets in anticancer immunotherapy. There …

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, is a complex
regulator of numerous cellular functions. GSK-3β is a unique kinase which is constitutively …

Abstract Histone lysine demethylase 1 (LSD 1), the first identified histone demethylase, is
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …