Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

Proteins are major targets for oxidative damage due to their abundance and rapid rates of
reaction with a wide range of radicals and excited state species, such as singlet oxygen …

Inevitable byproducts of aerobic metabolism are free radicals and other highly reactive
oxidants and nitrosants that are continuously formed within cells. Most cells generally …

Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is
important in antioxidant defense and redox signaling. We have examined its reactivity with …

This review provides a comprehensive overview of the functional roles of disulfide bonds
and their relevance to human disease. The critical roles of disulfide bonds in protein …

Reversible posttranslational modifications on specific amino acid residues can efficiently
regulate protein functions. O-Phosphorylation is the prototype and analogue to the rapidly …

Abstract Background Peroxiredoxins (Prxs) are a class of abundant thiol peroxidases that
degrade hydroperoxides to water. Prxs are sensitive to oxidation, and it is hypothesized that …

S-Glutathionylation (thiolation) is a ubiquitous redox-sensitive and reversible modification of
protein cysteinyl residues that can directly regulate their activity. While well established in …

With the rapid advance of MS-based proteomics one might think that 2D gel-based
proteomics is dead. This is far from the truth. Current research has shown that there are still …

The respiratory chain of the inner mitochondrial membrane is a unique assembly of protein
complexes that transfers the electrons of reducing equivalents extracted from foodstuff to …