Neurons rely mostly on mitochondria for the production of ATP and Ca2+ homeostasis. As
sub-compartmentalized cells, they have different pools of mitochondria in each compartment …

As key organelles involved in cellular metabolism, mitochondria frequently undergo
adaptive changes in morphology, components and functions in response to various …

Since our last comprehensive review on multi‐dimensional mass spectrometry‐based
shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the …

The brain is one of the most energy-consuming organs in the mammalian body, and
synaptic transmission is one of the major contributors. To meet these energetic …

Mitochondria are highly dynamic organelles with complex structural features which play
several important cellular functions, such as the production of energy by oxidative …

Lipidomics aims to quantitatively define lipid classes, including their molecular species, in
biological systems. Lipidomics has experienced rapid progress, mainly because of …

Recently, phospholipid peroxidation products gained a reputation as key regulatory
molecules and participants in oxidative signaling pathways. During apoptosis, a …

The brain contains a highly diversified complement of molecular species of a mitochondria-
specific phospholipid, cardiolipin, which, because of its polyunsaturation, can readily …

Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex
glycosphingolipids play very important roles in cell function under physiological conditions …

Otto Warburg first proposed that cancer originated from irreversible injury to mitochondrial
respiration, but the structural basis for this injury has remained elusive. Cardiolipin (CL) is a …