[HTML][HTML] Toward a mechanistic understanding of DNA methylation readout by transcription factors
Epigenetic DNA modification impacts gene expression, but the underlying molecular
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …
Structural conservation of antibiotic interaction with ribosomes
H Paternoga, C Crowe-McAuliffe, LV Bock… - Nature structural & …, 2023 - nature.com
The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …
Simulation of complex biomolecular systems: the ribosome challenge
Large biomolecular systems are at the heart of many essential cellular processes. The
dynamics and energetics of an increasing number of these systems are being studied by …
dynamics and energetics of an increasing number of these systems are being studied by …
[HTML][HTML] Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination
L Krause, R Herbst-Irmer, GM Sheldrick… - Journal of applied …, 2015 - scripts.iucr.org
The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …
compared for six model compounds with a wide range of absorption factors. The …
The RNA modification database, RNAMDB: 2011 update
WA Cantara, PF Crain, J Rozenski… - Nucleic acids …, 2010 - academic.oup.com
Since its inception in 1994, The RNA Modification Database (RNAMDB, http://rna-mdb. cas.
albany. edu/RNAmods/) has served as a focal point for information pertaining to naturally …
albany. edu/RNAmods/) has served as a focal point for information pertaining to naturally …
Engineered nucleic acids encoding a modified erythropoietin and their expression
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Terminally modified RNA
T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
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Engineered nucleic acids and methods of use thereof
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …
Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA
D Theler, C Dominguez, M Blatter, J Boudet… - Nucleic acids …, 2014 - academic.oup.com
N6A methylation is the most abundant RNA modification occurring within messenger RNA.
Impairment of methylase or demethylase functions are associated with severe phenotypes …
Impairment of methylase or demethylase functions are associated with severe phenotypes …
Modified polynucleotides for the production of biologics and proteins associated with human disease
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …