Therapeutic potential of certain terpenoids as anticancer agents: a scoping review

S Kamran, A Sinniah, MAM Abdulghani, MA Alshawsh - Cancers, 2022 - mdpi.com
Simple Summary Terpenoids are bioactive compounds with a variety of pharmacological
activities, including anticancer activity. This review paper aimed to focus on the anticancer …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance

T Biswas, UN Dwivedi - Protoplasma, 2019 - Springer
The saponins are a diverse class of natural products, with a broad scale distribution across
different plant species. Chemically characterized as triterpenoid glycosides, they posses a …

Betulinic acid: recent advances in chemical modifications, effective delivery, and molecular mechanisms of a promising anticancer therapy

M Ali‐Seyed, I Jantan, K Vijayaraghavan… - Chemical biology & …, 2016 - Wiley Online Library
An important method of drug discovery is examination of diverse life forms, including
medicinal plants and natural products or bioactive compounds isolated from these sources …

Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action

SIA Mohamed, I Jantan, MA Haque - International Immunopharmacology, 2017 - Elsevier
Natural products with immunomodulatory activity are widely used in treatment of many
diseases including autoimmune diseases, inflammatory disorders in addition to cancer …

Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells

GA Malfa, B Tomasello, R Acquaviva… - International journal of …, 2019 - mdpi.com
Betula etnensis Raf.(Birch Etna) belonging to the Betulaceae family grows on the eastern
slope of Etna. Many bioactive compounds present in Betula species are considered …

Chaga (Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung …

A Géry, C Dubreule, V André, JP Rioult… - Integrative cancer …, 2018 - journals.sagepub.com
Background: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on
birches and used in traditional medicine (especially by Khanty people) to treat various …

Modified gold nanoparticles for efficient delivery of betulinic acid to cancer cell mitochondria

O Oladimeji, J Akinyelu, A Daniels, M Singh - International Journal of …, 2021 - mdpi.com
Advances in nanomedicine have seen the adaptation of nanoparticles (NPs) for subcellular
delivery for enhanced therapeutic impact and reduced side effects. The pivotal role of the …

Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines

F Yakop, SA Abd Ghafar, YK Yong… - Artificial Cells …, 2018 - Taylor & Francis
Purpose: The purpose of this study was to investigate apoptotic activity of silver nanoparticle
Clinacanthus nutans (AgNps-CN) towards HSC-4 cell lines (oral squamous cell carcinoma …

Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 …

Z Peng, Y Wang, J Fan, X Lin, C Liu, Y Xu, W Ji… - Scientific Reports, 2017 - nature.com
Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in
two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone (Dehy) …