It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …

Protein–ligand interactions have been commonly studied through static structures of the
protein–ligand complex. Recently, however, there has been increasing interest in …

Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases
to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory …

Rad6, an E2 ubiquitin-conjugating enzyme conserved from yeast to humans, functions in
transcription, genome maintenance, and proteostasis. The contributions of many conserved …

Ubc13 is an E2 ubiquitin conjugating enzyme that functions in nuclear DNA damage
signaling and cytoplasmic NF-κB signaling. Here, we present the structures of complexes of …

Protein phosphorylation is a modification that offers a dynamic and reversible mechanism to
regulate the majority of cellular processes. Numerous diseases are associated with aberrant …

Cells are exposed to thousands of DNA damage events on a daily basis. This damage must
be repaired to preserve genetic information and prevent development of disease. The most …

Summary Ring1-YY1-binding protein (RYBP) is a member of the non-canonical polycomb
repressive complex 1 (PRC1), and like other PRC1 members, it is best described as a …

NMR is ideally suited for the analysis of protein–protein and protein ligand interactions with
dissociation constants ranging from~ 2 μM to~ 1 mM, and with kinetics in the fast exchange …

Malfunction of the ubiquitin (Ub) E3 ligase, parkin, leads to defects in mitophagy and protein
quality control linked to Parkinson's disease. Parkin activity is stimulated by phosphorylation …