Type 1 diabetes mellitus (T1DM) arises from the failure of pancreatic β-cells to produce
adequate insulin, usually as a consequence of extensive pancreatic β-cell destruction …

Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …

Reactive oxygen species (ROS) are implicated in induction of inflammatory response and
cartilage degradation in osteoarthritis (OA). Melatonin has been shown to improve the …

Background Pancreatic fibrosis is one of the most important pathological features of chronic
pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an …

This work aims to assess the recently established anti-inflammatory and antioxidant
potential of melatonin of plant origin extracted from the plant matrix as a phytomelatonin …

Hypoxia has an important role in tumor progression via the up-regulation of growth factors
and cellular adaptation genes. These changes promote cell survival, proliferation, invasion …

Various mechanisms have been suggested to explain the chemopreventive and tumor-
inhibitory effects of melatonin. Despite the growing evidence supporting melatonin-induced …

We have investigated the effects of melatonin on major pathways related with cellular
proliferation and energetic metabolism in pancreatic stellate cells. In the presence of …

Nonalcoholic steatohepatitis (NASH) is a disease with a high incidence worldwide, but its
diagnosis and treatment are poorly managed. In this study, NASH pathophysiology and DNA …

Purpose: The pathological process of atopic dermatitis (AD) progressing into other types of
allergic diseases such as asthma and allergic rhinitis during the first several years of life is …