The global demand is rising for greener manufacturing processes that are cost‐competitive
and available in a timely manner. This has led to the development of a series of new tools …

Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates
gene expression. A useful description of the TRN would decompose the transcriptome into …

Escherichia coli strains are widely used in academic research and biotechnology. New
technologies for quantifying strain-specific differences and their underlying contributing …

Recombinant proteins have been extensively employed as therapeutics for the treatment of
various critical and life-threatening diseases and as industrial enzymes in high-value …

Lipopolysaccharide and colanic acid are important forms of exopolysaccharides located on
the cell surface of Escherichia coli, but their interrelation with the cell stress response is not …

Background Despite the availability of numerous complete genome sequences from E. coli
strains, published genome-scale metabolic models exist only for two commensal E. coli …

N-acetylglucosamine (GlcNAc) is an amino sugar that has been widely used in the
nutraceutical and pharmaceutical industries. Recently, microbial production of GlcNAc has …

Nitrogen regulation in Escherichia coli is a model system for gene regulation in bacteria.
Growth on glutamine as a sole nitrogen source is assumed to be nitrogen limiting, inferred …

Background Escherichia coli exhibits diauxic growth in sugar mixtures due to CRP-mediated
catabolite repression and inducer exclusion related to phosphotransferase system enzyme …

Fast metabolite quantification methods are required for high throughput screening of
microbial strains obtained by combinatorial or evolutionary engineering approaches. In this …