Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Adolescence is a developmental period when physical and cognitive abilities are optimized,
when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal …

The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory
consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity …

The immediate early gene Arc is emerging as a versatile, finely tuned system capable of
coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing …

The treatment of alcoholism requires the proper management of ethanol withdrawal
symptoms, such as anxiety, to prevent further alcohol use and abuse. In this study, we …

The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

Binge drinking is common during adolescence and can lead to the development of
psychiatric disorders, including alcoholism in adulthood. Here, the role and persistent effects …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

In the present study, we used a mouse model of chronic intermittent ethanol (CIE) exposure
to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute …

Continued seeking and drinking of alcohol despite adverse legal, health, economic, and
societal consequences is a central hallmark of human alcohol use disorders. This …