Abstract In the United States, pancreatic cancer is the fourth most frequent cause of cancer
death in males as well as females, after lung, prostate or breast, and colorectal cancer. Each …

Gastric acid secretion is under nervous and hormonal control. Gastrin, the major circulating
stimulus of acid secretion, probably does not stimulate the parietal cells directly but acts to …

Ghrelin is a 28 aa gastric peptide, recently identified as a natural ligand of the growth
hormone secretagogue receptor (orphan receptor distinct from the receptor for growth …

We combined in vitro and in vivo methods to investigate the effects of ghrelin, a novel gastric
hormone, on insulin and glucagon release. Studies of isolated mouse islets showed that …

Both ghrelin and obestatin are derived from preproghrelin by post-translational processing.
We have morphologically characterized the cells that produce obestatin and ghrelin in new …

Background/Aims In the presence of atrophic body gastritis, gastric carcinoid develops from
gastric-body mucosa enterochromaffin-like cells. Few data exist on the prevalence of …

Ghrelin, a recently discovered peptide hormone, is produced by endocrine cells in the
stomach, the so-called A-like cells. Ghrelin binds to the growth hormone (GH) secretagogue …

Background: Serum chromogranin A (CgA) is regarded as a reliable marker of
neuroendocrine proliferation. We previously described increased serum CgA levels during …

The peptide hormone gastrin, released from antral G cells, is known to stimulate the
synthesis and release of histamine from ECL cells in the oxyntic mucosa via CCK-2 …

In this paper, the estabished and possible roles of CCK1 and CCK2 receptors in
gastrointestinal (GI) and metabolic diseases are reviewed and available results from human …