Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Abstract Oxidative modification of 5-methylcytosine (5mC) by ten-eleven translocation (TET)
DNA dioxygenases generates 5-hydroxymethylcytosine (5hmC), the most abundant form of …

Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Chromatin modifications–including DNA methylation, modification of histones and
recruitment of noncoding RNAs–are essential epigenetic events. Multiple sequential …

Innate immune cells play essential roles in modulating both immune defense and
inflammation by expressing a diverse array of cytokines and inflammatory mediators …

Ten-Eleven-Translocase (TET) enzymes contribute to the regulation of the methylome via
successive oxidation of 5-methyl cytosine (5mC) to derivatives which can be actively …

BACKGROUND: Despite advances in understanding hypertension's genetic structure, how
noncoding genetic variants influence it remains unclear. Studying their interaction with DNA …