Melatonin: another avenue for treating osteoporosis?

T Li, S Jiang, C Lu, W Yang, Z Yang… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Melatonin effects on bone: implications for use as a therapy for managing bone loss

F Munmun, PA Witt‐Enderby - Journal of pineal research, 2021 - Wiley Online Library
Melatonin is the primary circadian output signal from the brain and is mainly synthesized in
pinealocytes. The rhythm and secretion of melatonin are under the control of an …

Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons

S Xu, Z Zhou, L Zhang, Z Yu, W Zhang, Y Wang… - Brain research, 2010 - Elsevier
Increasing evidence indicates that oxidative stress may be involved in the adverse effects of
radiofrequency (RF) radiation on the brain. Because mitochondrial DNA (mtDNA) defects …

Melatonin as a chronobiotic/cytoprotective agent in bone. Doses involved

DP Cardinali - Journal of Pineal Research, 2024 - Wiley Online Library
Because the chronobiotic and cytoprotective molecule melatonin diminishes with age, its
involvement in postmenopausal and senescence pathology has been considered since …

Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects

A Bagherifard, A Hosseinzadeh, F Koosha… - Osteoporosis …, 2023 - Springer
Purpose Bone diseases account for an enormous cost burden on health systems. Bone
disorders are considered as age-dependent diseases. The aging of world population has …

Melatonin effects on hard tissues: bone and tooth

J Liu, F Huang, HW He - International journal of molecular sciences, 2013 - mdpi.com
Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the
control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an …

Melatonin and the skeleton

AK Amstrup, T Sikjaer, L Mosekilde… - Osteoporosis …, 2013 - Springer
Melatonin may affect bone metabolism through bone anabolic as well as antiresorptive
effects. An age-related decrease in peak melatonin levels at nighttime is well documented …

Scientific basis for the potential use of melatonin in bone diseases: osteoporosis and adolescent idiopathic scoliosis

EJ Sánchez-Barceló, MD Mediavilla… - Journal of …, 2010 - Wiley Online Library
The objective of this paper was to analyze the data supporting the possible role of melatonin
on bone metabolism and its repercussion in the etiology and treatment of bone pathologies …

Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis

DZ Wu, GZ Zhu, K Zhao, JW Gao, GX Cai, HZ Li… - Molecular …, 2024 - Springer
Background Increased oxidative stress contributes to enhanced osteoclastogenesis and age-
related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging …

Topical application of melatonin and growth hormone accelerates bone healing around dental implants in dogs

F Muñoz, M López‐Peña, N Miño… - … implant dentistry and …, 2012 - Wiley Online Library
Background: Growth hormone (GH) and melatonin belong to the group of growth factors.
These substances have been proposed to improve and accelerate osseous healing using …