Over the past three decades, extensive research has been able to determine the biologic
functions for the main bioactive sphingolipids, namely ceramide, sphingosine, and …

Ceramide and sphingosine are important interconvertible sphingolipid metabolites which
govern various signaling pathways related to different aspects of cell survival and …

Sphingolipids have emerged as key regulatory molecules in cancer cell survival and death.
Although important roles of sphingolipids in breast cancer progression have been reported …

Sphingolipid metabolism is known to play a role in cell death, survival, and therapy
resistance in cancer. Sphingolipids, particularly dihydroceramide and ceramide, are …

Background: Chalcones are structurally simple compounds that are easily accessible by
synthetic methods. Heterocyclic chalcones have gained the interest of scientists due to their …

Background: Acrylamide is a very common compound even reaching up to our daily foods. It
has been studied in a wealth of cell lines on which it proved to have various toxic effects …

Ceramide is found to be involved in inhibition of cell division and induction of apoptosis in
certain tumour cells. Ceranib-2 is an agent that increases ceramide levels by inhibiting …

Acid ceramidase catalyzes the degradation of ceramide into sphingosine and a free fatty
acid. Acid ceramidase deficiency results in lipid accumulation in many tissues and leads to …

Sphingolipids are important constituents of the eukaryotic cell membrane which govern
various signaling pathways related to different aspects of cell survival. Ceramide and …

Cancer is a complex disease with high mortality rates. Breast cancer is one of the most fatal
diseases both for men and woman. Despite the positive developments on cancer treatment …