Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …

Enhancer of Zeste [E (z)] is a Polycomb-group transcriptional repressor and one of the
founding members of the family of SET domain-containing proteins. Several SET-domain …

Whole-genome sequence assemblies are now available for seven different animals,
including nematode worms, mice and humans. Comparative genome analyses reveal a …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

Chromatin structure creates barriers for each step in eukaryotic transcription. Here we
discuss how the activities of two major classes of chromatin-modifying complexes, ATP …

In biennials and winter annuals, flowering is typically blocked in the first growing season.
Exposure to the prolonged cold of winter, through a process called vernalization, is required …

ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation
represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex …