In pathophysiology, reactive oxygen species control diverse cellular phenotypes by
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …

Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being
detected peripherally as well as associated with the vulnerable regions of the brain affected …

Iron homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess
iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Mitochondria are uniquely poised to play a pivotal role in neuronal cell survival or death
because they are regulators of both energy metabolism and cell death pathways. Extensive …

Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two
pathological hallmarks; the accumulation of aggregated amyloid beta and excessively …

Alzheimer's Disease (AD) is complicated by pro-oxidant intraneuronal Fe 2+ elevation as
well as extracellular Zn 2+ accumulation within amyloid plaque. We found that the AD β …

Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …