As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated
levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic …

Context In recent years, the ketogenic diet has gained special relevance as a possible
therapeutic alternative to some neurological and chronic diseases. Objective The aim of this …

Prediabetes and Alzheimer's disease both increase in prevalence with age. The former is a
risk factor for the latter, but a mechanistic linkage between them remains elusive. We show …

Introduction Epidemiological studies indicate an association between type 2 diabetes and
cognitive dysfunction that appear to start already in the prediabetic state. Although cross …

The prevalence of both Alzheimer's disease (AD) and vascular dementia (VaD) is increasing
with the aging of the population. Studies from the last several years have shown that people …

Insulin is a hormone typically associated with pancreatic release and blood sugar
regulation. The brain was long thought to be “insulin-independent,” but research has shown …

Alzheimer's disease is a quintessential 'unmet medical need', accounting for∼ 65% of
progressive cognitive impairment among the elderly, and 700,000 deaths in the United …

Clinical trials have extensively failed to find effective treatments for Alzheimer's disease (AD)
so far. Even after decades of AD research, there are still limited options for treating …

Over the past decade, a wide range of scientific investigations have been performed to
reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic …

Objective To examine whether midlife insulin resistance is an independent risk factor for
brain amyloid accumulation in vivo after 15 years, and whether this risk is modulated by …