Abstract GH and IGF-I and-II were first identified by their endocrine activity. Specifically, IGF-I
was found to mediate the linear growth-promoting actions of GH. It is now evident that these …

Growth hormone (GH) is a major regulatory factor for overall body growth as evidenced by
the height extremes in people with abnormal circulating GH levels or GH receptor (GHR) …

GH exerts a diverse array of physiological actions that include prominent roles in growth and
metabolism, with a major contribution via stimulating IGF-1 synthesis. GH achieves its effects …

The growth hormone receptor has been an archetype for ligand-induced receptor
dimerisation in cytokine receptor signalling. However, we now know that it exists as a …

Several clinical observations and experimental studies indicate that pituitary hormones,
including growth hormone, play a role in the development of human breast cancer. We …

Recent published data have demonstrated elevated levels of human GH (hGH) in
endometriosis and endometrial adenocarcinoma. Herein, we demonstrate that autocrine …

The production and utilization of common ligands and their receptors by cells of the immune
and neuroendocrine systems constitutes a biochemical information circuit between and …

Age-related sarcopenia inhibits mobility, increasing the risk for developing many diseases,
including diabetes, arthritis, osteoporosis, and heart disease. Tissue plasticity, or the ability …

In this review we consider the evidence that growth hormone (GH) acts in the embryo as a
local growth, differentiation, and cell survival factor. Because both GH and its receptors are …

Clinical trials and laboratory-based studies indicate that the growth hormone/insulin-like
growth factor-I axis may affect the development of breast cancer. The purpose of the present …